This study aimed to analyze the postoperative pathological t‐CEA and preoperative s‐CEA expressions, and their correlation with clinicopathological features; to determine the relationship between s‐CEA and t‐CEA and the 5‐year disease‐free survival rate using single and multiple factors; and to further explore the relationship between independent factors and CRC prognosis. This evidence concerns the gene CEACAM5 and colorectal carcinoma.