TGFB1 and cancer: This process enhances the motility and invasion of cancer cells and plays an important part in the consensus molecular subtype (CMS) classifications.23 CRCs with EMT signature are classified into CMS4 subgroup (an EMT‐related subtype), characterized as more aggressive phenotype showing poorer overall survival and signatures of high TGF‐β signaling and EMT activation.7 Tumor budding, with single cells or clusters of up to five cells detached from the main tumor mass, is the morphologic manifestation of EMT.