MMP9 and hepatocellular carcinoma: Yamamoto et al reported that CTHRC1 activated the Wnt/PCP pathway by stabilizing the Wnt‐receptor complex and suppressing the canonical Wnt pathway.28 CTHRC1 could promote the proliferation and invasiveness of colorectal cancer cell by activating Wnt/PCP signaling.29 In hepatocellular carcinoma, CTHRC1 knockdown suppressed cell migration/invasion and induced apoptosis via integrin β downregulation.30 Kim et al16 proved that CTHRC1 could activate the Src and Erk signaling cascades and upregulate matrix metalloproteinase 9 (MMP9), thus promote colorectal cancer cell invasion.