Consistently, Hou et al found that CTHRC1 promotes EMT in ovarian cancer.21 Jin et al reported that the knockdown of CTHRC1 inhibits EMT in renal cell carcinoma.27 Taken together, these data suggested that CTHRC1 might play an extensive oncogenic role by inducing the process of EMT and thus promote CRC cells invasion and migration. This evidence concerns the gene CTHRC1 and hereditary clear cell renal cell carcinoma.