CTHRC1 was initially described as a glycosylated 28‐kDa protein secreted during the injury‐repair process.9 The overexpression of CTHRC1 has been demonstrated to act as a key regulator of cell migration by reducing collagen matrix deposition in injured arteries.9 While physiological CTHRC1 expression is essential for wound healing, the pathological reactivation of CTHRC1 drives human tumor development. The gene discussed is CTHRC1; the disease is neoplasm.