In vascular cells, CTHRC1 regulated TGF‐β responsiveness9 and reversed TGF‐β‐stimulated collagen expression.17 Due to the modulation of TGF‐β in the EMT process during cancer cell migration, we proposed that CTHRC1 might be involved in TGF‐β ‐related EMT and CRC metastasis.8 The gene discussed is CTHRC1; the disease is cancer.