Collagen triple helix repeat containing 1 (CTHRC1) was first discovered in balloon‐injured rat arteries, where it is involved in vascular remodeling and promoting cell migration.9, 10 In cancerous tissue, CTHRC1 was overexpressed in most solid tumors,11, 12, 13, 14 including CRC.15, 16 However, the underlying mechanism of CTHRC1 activation is largely unknown. Here, CTHRC1 is linked to colorectal carcinoma.