CTHRC1 and breast cancer: Some investigators reported that upregulated CTHRC1 acts as a prognostic factor in melanoma14 and breast cancer.22 In addition, Tan et al demonstrated that increased expression of CTHRC1 occurs in peritoneal carcinomatosis of CRC and predicts prognosis in CRC patients.15 Our results verified that the overexpression of CTHRC1 in CRC patients results in poor outcomes.