Regulatory T (Treg) cells are a subpopulation of CD4+ T‐cell that inhibit effector T‐cell responses, with increased Treg infiltration in cancer associating with poor survival.302, 303 Compared to naïve CD4+ cells, Tregs contain more autophagosomes and have higher LC3‐II levels indicating the presence of increased levels of autophagy.304 Knockout of autophagy genes induced apoptosis of Treg cells and blocked Treg‐mediated suppression of effector T‐cell responses. Here, CD4 is linked to cancer.