However, upon taxol treatment in hypoxic conditions cancer cells did appear to activate cytoprotective autophagy through inhibition of the mTOR pathway.213 Similarly, chemotherapy resistance in triple‐negative breast CSCs was attributed to a combination of hypoxia and upregulation of autophagy occurring in xenograft models from these patients.214 Overall, this data implies that hypoxia‐mediated resistance to therapy is at least partly due to the induction of cytoprotective autophagy. This evidence concerns the gene MTOR and cancer.