TP53 and cancer: For instance, wildtype p53 is depleted via autophagy‐mediated degradation in renal cell carcinoma, which allows escaping from apoptotic cell death.137 In contrast, suppression of macroautophagy promotes the degradation of mutant p53 via CMA, which sensitizes various human cancer cell lines for cell death.138 Further, a truncated p53 isoform that inhibits wildtype p53 is degraded via autophagy.139