Similar to Beclin‐1, allelic loss of the autophagy component UVRAG or reduced expression of Bif‐1, both direct interactors with Beclin‐1, is also associated with cancer development, in this case, gastric and colon cancer.71, 72, 73 In brief, UVRAG forms a complex with Beclin‐1 to activate autophagy and loss of this protein resulted in impaired autophagy. The gene discussed is UVRAG; the disease is malignant colon neoplasm.