IFNG and cancer: Indeed, inhibition of autophagy augmented cell surface expression of MHC‐I induced by treatment of melanoma cells with the immunostimulatory cytokine interferon γ (IFNγ).243 Importantly, the loss of MHC‐I expression (“missing self”) is also being recognized by NK cells, leading to the elimination of the cancer cell.241 However, several reports detail that high levels of autophagy in cancer cells reduces the efficacy of NK and CTL‐mediated cell lysis.