TP53 and acute myeloid leukemia: For instance, elevated levels of autophagy were identified in mutant p53 expressing AML cells, whereas a reverse reduction in autophagy was detected in pancreas and breast cancer cell lines that expressed mutant p53.108, 127 These apparent contradictory data may be explained by the localization of p53, since p53 mutants that localized to the cytosol repressed autophagy, whereas p53 mutants localized to the nucleus did not.128 These clear differences in the effect of p53 mutants on autophagy may also impact on therapeutic response toward autophagy inhibition.