For instance, oncogenic FLT3–ITD–positive AMLs cells are characterized by high levels of autophagy.122 Both pharmacological as well as genetic inhibition of autophagy in FLT3‐ITD in human AML cells markedly reduced cell proliferation and overcame acquired resistance to FLT3 inhibitors in mice. The gene discussed is FLT3; the disease is acute myeloid leukemia.