In a similar fashion, IL‐6 and IL‐8 secretion by CAFs was reduced upon knockdown of Beclin‐1, which decreased migration of HNSCC cells.216 Of note, direct addition of IL‐6 and IL‐8 to HNSCC cells promoted migration to a similar extent as coculture with CAFs, highlighting the importance of those cytokines for the autophagy‐mediated effect of fibroblasts. The gene discussed is CXCL8; the disease is head and neck squamous cell carcinoma.