GABARAPL1 and breast carcinoma: Further, disruption of Beclin‐1/UVRAG/BIF‐1 may cause genomic instability.75 In addition, GABARAPL1, an autophagy gene involved in of the initiation of autophagosome formation, was found to be downregulated in breast cancer, in this case, due to altered DNA methylation and histone deacetylation patterns.76 The functional outcome of downregulation of GABARAPL1 was a reduction in autophagic flux and increased tumorigenesis.77