Correspondingly, granzyme B was predominantly detected in LC3 and Rab5‐positive fractions in hypoxic cells.246 Hence, autophagy in cancer cells contributed to resistance to lysis of lung cancer cell lines, breast cancer cells, and melanoma cells in hypoxic conditions by degrading granzyme B.246, 247, 248 A similar effect was detected upon hypoxia‐independent activation of HIFs, as seen in renal cancer with mutations in the von Hippel‐Lindau gene. This evidence concerns the gene GZMB and breast carcinoma.