Cancer-associated fibroblasts (CAFs) contribute to carcinogenesis through the development of unique functions, including an amplified extracellular matrix (ECM) production, higher proliferation rate and the secretion of several cytokines, like vascular endothelial growth factor (VEGF), stromal cell-derived factor 1 (SDF1) and platelet-derived growth factor (PDGF), leading to angiogenesis [40]. Here, VEGFA is linked to cancer.