A subset of NF1 minipigs exhibited other abnormalities described in NF1 patients, including freckling (30.8%, 4/13 animals) and congenital hypopigmentation of the hair, with no underlying melanin changes in the skin (23.1%, 3/13 animals) (Supplementary Figure 1, Table 1)1,4,5. The gene discussed is NF1; the disease is neurofibromatosis type 1.