SHANK3 and premenstrual tension: Moreover, the expression and alternative splicing of Shank3 isoforms or even their subcellular distribution has been shown to be cell-type specific, activity dependent as well as regionally and developmentally regulated (Wang et al., 2014) raising the possibility that differing SHANK3 isoforms may play distinct roles in synaptic developmental and function and hence may make distinct contributions to the pathobiology of PMS.