KDR and neoplasm: Recently, a phase I clinical trial was conducted in patients with stage IV pancreatic cancer, which used Salmonella Typhi Ty21a for bactofection of a plasmid with the human VEGFR-2 sequence (overexpressed protein on endothelium of tumor microenvironment); its aim was to induce an antiangiogenic response and memory immune response against endothelial cells to eliminate tumor vascularization [127].