CD8A and melanoma: Likewise, orogastric immunization with Salmonella Typhimurium, which translocates the immunogenic epitope of the murine vascular endothelial growth factor receptor 2 (VEGFR-2) via T3SS, induced an antigen-specific immune response by CD8+ T lymphocytes, in a murine melanoma model, and decreased metastases up to 60% in the immunized mice [109].