TNF and malignant colon neoplasm: Salmonella enterica was recently used to transport 4-1IBBL molecules, a member of the TNF family, and CEACAM 6 molecules, a cellular adhesion molecule, in a rat colon cancer model; the immunization with Salmonella enterica carrying those antigens avoided tumor progression, decreased the numbers of Treg cells, promoted a Th1 response, and increased the numbers of CD45RO+ memory T-cells [113].