Salmonella Typhimurium has indeed been used to transport immunomodulating proteins such as LIGHT [114], interleukin-18 [115], and the chemokine CCL21 [33], in breast cancer and colon cancer murine models; in all cases, regression of the primary tumor was observed as well as of its pulmonary metastases, where the antitumor activity was associated to the recruitment of DCs, macrophages, neutrophils, NK cells, and lymphocytes. The gene discussed is IL18; the disease is neoplasm.