On the other hand, the activation of TLR5 by the flagellin of Salmonella Typhimurium fused with peptide P10 of the gp43 protein of Paracoccidioides brasiliensis eliminated the development of metastases in the melanoma murine model [83], and the use of a TLR5 agonist displayed antitumor effects in a murine lymphoma model while also promoting the activation of CD8+ lymphocytes and NK cells [84]. Here, CD8A is linked to melanoma.