TGFB1 and neoplasm: In spite of the discrepancies between the mechanisms used by Salmonella enterica to colonize the tumor, once Salmonella enterica reaches the tumor, its permanence in the tissue is associated to low macrophage and neutrophil activity due to the hypoxia within the tumor [32] and to the suppression of the immune response mediated by cytokines such as TGF-β [19] and the difficult access to the tumor microenvironment of preexisting anti-Salmonella antibodies and complement cascade factors due to the irregular growth of blood vessels in the tumor microenvironment [33].