TNF and neoplasm: Although the mechanisms involved in the initial recruitment of these cells, after intratumoral administration of Salmonella enterica, remain under study [88], this process could begin by recognizing bacterial LPS via TLR4, leading to increased TNF-α levels [89], which provoke hemorrhage from the blood vessels in the tumor, thus promoting infiltration of the immune response cells, which will initiate the tumor elimination process [90] (Figure 2(b)).