With these reactions, it is also possible to explain the negative correlation of T/NK cell modules, as these cells are very quickly recruited to lymphoid tissues following acute innate immune response such as virus infections.25 The negative correlation of cell cycle BTM could be related to the same mechanisms as T cell represent the main cell fraction in PBMC and many such BTM were actually related to T cells, in particular CD4 T cells. Here, CD4 is linked to viral infectious disease.