A series of germ cell-like cells from primordial germ cells (PGCs) to later oocyte-like cells17 could be observed and colocalized with Oct4-GFP signal in cultured p53−/− BMDCs (Fig. 1b–e), as determined by the expression of a series of germ cell special markers15,16, including Oct4, nonspecific alkaline phosphatase (AP), Nanog, Nanos3, Sox2, deleted in azoospermia-like (DAZL), and growth differentiation factor (GDF9) in these cells (Fig. 1c, Supplementary Fig. S1b-d). The gene discussed is SOX2; the disease is Azoospermia.