TP53 and neoplasm: Four weeks after treatment with chemotherapy agents, such as taxol, etoposide, or cisplatin, or 16 days after treatment with high dose of γ-irradiation (15 Gy), oocyte-like large cells and their derivatives with embryo-like structures survived and were enriched in p53−/− HCT116 cells but were rarely detected in p53+/+ HCT116 cells, whereas almost all somatic tumor cells and most of earlier germ cell-like cells were eliminated both in p53−/− HCT116 and p53+/+ HCT116 cells (Fig. 6d, Supplementary Fig. S4b).