Some of them are well known to be increased in atherosclerosis such as apolipoprotein E (ratio = 10.82), ApoB (ratio = 14.53) and APOA1 (ratio = 17.33) as well as paraoxonase 3 (PON3) (ratio = 45.74)19,20 (supplementary Table S2). This evidence concerns the gene APOE and atherosclerosis.