GJA1 and hydrops fetalis: A hallmark of the electrical disorders with regard to impulse conduction in heart failure (HF) is the electrical uncoupling due to diminished presence of Cx43 in gap junctions, resulting in slowed conduction velocity (CV) and dispersed impulse propagation leading to an increased risk of re-entrant excitation, predisposing to cardiac arrhythmia and even sudden cardiac death3–5.