GJA1 and hydrops fetalis: (3) On the contrary, overexpression of CCRR abrogates the conduction anomalies in the setting of HF, and CCRR was required for maintaining proper distribution of Cx43 in the intercalated discs by binding to CIP85 protein so as to prevent Cx43 from backward trafficking and subsequent degrading, which likely served as a downstream mechanism for the disruption of gap junction (Fig. 10).