ADGRG6 and androgen insensitivity syndrome: While the etiology of adolescent idiopathic scoliosis (AIS) is not well understood, recent genome-wide association studies have identified common variants near neural cell adhesion molecules4, ladybird homeobox 1 (LBX1)5, G-protein-coupled receptor 126 (GPR126)6, and the transcription factor BNC27 that are modestly associated with AIS.