SLC39A8 and androgen insensitivity syndrome: Here we present an exome-wide association study of severe adolescent idiopathic scoliosis and identify an association with a missense SNP in the gene SLC39A8. We replicate this finding in a second independent cohort and show that in addition to scoliosis risk, the SNP is associated with several related traits in our AIS cohort including height, BMI, and curve severity.