Genes mutated in both datasets of MM patients include Trp53, Zfhx4, Fgfr3, Fat3, Fat4 and Lrp1b. Other overlapping genes mutated in one dataset include Nf1, Robo1 and Rb1. In conclusion, we found a statistically significant overlap of mutated genes in the 5TMM models and the human situation with Trp53 and Rb1 being the most interesting. This evidence concerns the gene LRP1B and Miyoshi myopathy.