For the two tumor samples with the highest mutation rates, the only LoF mutation shared between both tumors is a heterozygous 9-base germline insertion in exon 1of MSH3 (Supplementary Table 2 and Supplementary Fig. 3), which was amplified in copy number and had (allele frequency > 0.9 in both samples) complete loss of heterozygosity (LOH) in both tumor samples. The gene discussed is MSH3; the disease is neoplasm.