APEX1 and Miyoshi myopathy: Furthermore, a chromatin immunoprecipitation (ChIP) assay showed that both APEX1 and P73 bind to RAD51 promoter in MM cells; and inhibition of APEX1 by small molecule inhibitor or shRNA-mediated APEX1 knockdown, inhibits the association of P73 with RAD51 promoter (Fig. 4b I-IV).