It was shown previously, that this mouse line gains its construct validity as a model of schizophrenia from (1) a hypofunction of parvalbumin-positive interneurons, (2) reduced hippocampal volume, and (3) a lack of adult neurogenesis - three cellular pathologies observed in schizophrenia2,15,16,20–22,37. The gene discussed is PVALB; the disease is schizophrenia.