NFKB1 and diffuse large B-cell lymphoma: Using the MWCL-A20ko and HBL-1-A20ko, we were able to show that loss of TNFAIP3 enhances MYD88L265P-driven NF-κB and p38 signaling resulting in increased expression of NF-κB target genes IL-6 and CXCL10, known NF-κB target genes2,32,38,39, have both been shown to be significantly upregulated in WM and DLBCL, and higher serum levels correlate with an inferior survival38,40–43.