Using the MWCL-A20ko and HBL-1-A20ko, we were able to show that loss of TNFAIP3 enhances MYD88L265P-driven NF-κB and p38 signaling resulting in increased expression of NF-κB target genes IL-6 and CXCL10, known NF-κB target genes2,32,38,39, have both been shown to be significantly upregulated in WM and DLBCL, and higher serum levels correlate with an inferior survival38,40–43. This evidence concerns the gene CXCL10 and diffuse large B-cell lymphoma.