The potential complexity of ascorbate engagement with immune cells in the tumour microenvironment is well demonstrated by the observations that dendritic cells treated with ascorbate secreted increased levels of IL-12p70 after activation with LPS and induced more Th1 cytokine and IFN-γ, but less Th2-cytokine, IL-5 expression in naive T cells [95]. Here, IFNG is linked to neoplasm.