CRP and post-traumatic stress disorder: This in turn leads to alterations in neurotransmission and apoptosis.25 The pro-inflammatory state has also been demonstrated to significantly suppress hippocampal neurogenesis and high titres are associated with low hippocampal volume,26 a neuroanatomical trait that marks vulnerability to PTSD.27 It is possible that a rise in pro-inflammatory cytokines and subsequently CRP may be regarded as representing a biological response to trauma just as PTSD represents the parallel psychological response.