These analyses revealed that the change in PAI-1 between 1- and 3-years progressively increased from the normal GCT NGT group to the abnormal GCT NGT to GIGT to GDM (P = 0.03), whereas the concurrent changes in adiponectin, chemerin, RBP-4 and CRP did not differ across the groups (Fig. 1). This evidence concerns the gene SERPINE1 and gestational diabetes.