2015). This is the first study to find that the DIM plus DOC combination decreases MnSOD protein expression. We found that the expression of MnSOD decreased to a greater extent with the combination treatment than with DIM or DOC alone, which was associated with increased ROS. Highly invasive MDA-MB231 cells and HER2 positive Sk-BR-3 cells have elevated levels of MnSOD compared to ER + breast cancer cell lines (Kattan et al. 2008). Suppression of MnSOD expression with antisense RNA increased H2O2 and reduced proliferation and tumor growth (Kattan et al. 2008). This evidence concerns the gene ESR1 and neoplasm.