The mean tumor weight was 0.92 ± 0.16 and 0.85 ± 0.12g in mice treated with cisplatin and GRN A, respectively, while the tumor weight reduced to 0.65 g in mice treated with the combination of cisplatin and GRN A. Importantly, the body weight of the mice was less affected in mice treated with the combination of the two drugs, compared with those treated with cisplatin alone. This evidence concerns the gene GRN and neoplasm.