In previous studies, GLP-1R agonists such as GLP-1, Exenatide, and Liraglutide, present multiple biological actions in type 2 diabetes, including restoration glucose-dependent stimulation of insulin secretion, more adequate insulin secretory response after meals, suppression of glucagon secretion, and enhancement of glucagon secretion when plasma glucose is low [26]. The gene discussed is INS; the disease is type 2 diabetes mellitus.