Several peptides were Food and Drug Administration (FDA)-approved, including an acylated GLP-1 named liraglutide, a GLP-1 analog exendin-4 found in Gila monster, and a sequence-modified exendin-4 named lixisenatide, while the risks of pancreatic, renal, and immune diseases limits their clinical application [9,10,11,12]. This evidence concerns the gene GLP1R and immune system disorder.