PAC-14028 is a potent TRPV1 inhibitor with an IC50 value of 55.0 ± 7.1 nM against capsaicin-induced calcium influx in rat DRG neurons, and it can attenuate dermatitis-associated barrier damages in Dermatophagoides farina- and oxazolone-induced mouse models of AD [135]. This evidence concerns the gene TRPV1 and Alzheimer disease.