The results demonstrated that the DEGs were enriched in lots of signal pathways, of which the main enriched terms were “viral carcinogenesis”, “Alcoholism”, “Systemic lupus erythematosus”, “MAPK signaling pathway”, “steroid biosynthesis”, “TGF-beta signaling pathway”, “MicroRNAs in cancer”, “PPAR signaling pathway”, “Salivary secretion”, “Amoebiasis”, “Estrogen signaling pathway” and “signaling pathways regulating pluripotency of stem cells”(Figure 4). Here, PPARA is linked to alcohol dependence.