NOS1 and Hypertension: Consistent with our previous findings that resveratrol decreases BP better than rosuvastatin, abolishes ROS generation, and enhances activity of the ERK1/2-RSK-nNOS pathway by activating 5′ AMP-activated protein kinase (AMPK) to negatively regulate Racl-induced NADPH oxidase levels in the NTS during oxidative stress-associated hypertension [40].