Preclinical studies related to DM, acute myocardial infarction (AMI), wound healing and chronic vascular inflammatory diseases indicated increased activation of endogenous SHH signaling pathway in non-treated group compared to that of the treated group, wherein exogenous administration of SHH promoted functional recovery of EPCs, resulting in enhanced angiogenesis, cardiomyogenesis and wound healing [26,54,55]. This evidence concerns the gene SHH and acute myocardial infarction.