SREBF1 and posterior cortical atrophy: In conclusion, these results demonstrated for the first time that: (1) GTEE, a traditional Chinese medicine, inhibited the expression of SREBP-1, FASN, and AR in both androgen-responsive and castration-resistant PCa cells; (2) GTEE decreased the amounts of intracellular fatty acid and lipid in PCa cells; and 3) blockade of the SREBP-1/AR axis by GTEE resulted in significant inhibition of cell growth, migration and invasion, as well as induction of apoptosis via the caspase-associated pathway in PCa cells (Figure 5D).