It has been shown that PI3K-Akt activation is required for the induction of membrane type 1 metalloproteinase (MT1-MMP) [66,67], a transmembrane MMP that plays a major role in extracellular matrix remodeling; directly by degrading several of its components and indirectly by activating pro-MMP2, an ubiquitinous MMP that is involved in diverse functions such as angiogenesis and tumor invasion, as well as degradation of extracellular matrix proteins [68]. The gene discussed is MMP14; the disease is neoplasm.