Loveridge et al. demonstrated that the NSAIDs sulindac, sulindac sulphone, and indomethacin induce nucleolar translocation of RelA in colon cancer cell lines, demonstrated that this was dependent on the N-terminal NoLS and showed that blocking nucleolar translocation of RelA blocked the apoptotic effects of these agents [63]. The gene discussed is RELA; the disease is malignant colon neoplasm.