To extend these studies to an in vivo setting that represents the AML hierarchy and clonal variety of primary AML, we tested the anti-leukemic effect of palbociclib in a mouse leukemia model expressing a C-terminally truncated isoform of RUNX1/ETO, termed RUNX1/ETO9a (Draper et al., 2016, Yan et al., 2006). This evidence concerns the gene RUNX1 and acute myeloid leukemia.