The majority of patients were HIV co-infected (278/333; 84.2%), with a low median CD4 cell count of 88.5 cells/mm3 (IQR: 27.0–234.5) and more than half (139/260; 53.5%) having a CD4 cell count ≤100 cells/mm3 at RR/MDR-TB treatment initiation. Here, CD4 is linked to tuberculosis.