However, the authors of this COST Action remind the readership that, with the only exception of certain disruptive mutations in some (but not all) DSD-related genes (e.g., the androgen receptor gene and a few more), molecular diagnosis cannot reliably predict the functional consequences for an individual DSD case (e.g., the potential of steroid biosynthesis by the gonads or by the adrenals or the sensitivity to sex steroids), which are important aspects for individualised clinical management. This evidence concerns the gene AR and disorder of sexual differentiation.