To date, accumulating studies showed that the Gαq pathway activated pathological hypertrophy including Gαq/PLC/Ca2+, PKC pathway, gp130/JAK/STAT signal pathway, and the IGF1‐PI3K pathway activated physiological hypertrophy.3 Although several signal‐transduction pathways contributed to the hypertrophic process have been studied in recent years, it is still not fully to clear underlying molecular mechanisms for cardiac hypertrophy. The gene discussed is GNAQ; the disease is cardiac hypertrophy.