STRIT1 and heart failure: Second, it has been shown that MLP KO mice exhibit the characteristic cardiomyocyte Ca2+ cycling defects that are acquired in human heart failure, including reductions in peak cardiomyocyte Ca2+ transient amplitude and prolongation of Ca2+ reuptake kinetics, which relates to decreased SERCA activity (Arber et al., 1997), and these are the specific parameters that should be enhanced with DWORF overexpression.