While many cases of DCM are idiopathic in nature, direct links have been established between the development of DCM as a consequence of inflammatory, metabolic, or toxic insults or by genetic mutations in Ca2+ regulatory proteins, contractile proteins or cytoskeletal proteins that reside at the sarcomeric Z-disc (Arber et al., 1997; Cahill et al., 2013; McNally et al., 2013). Here, DNM2 is linked to familial dilated cardiomyopathy.