Quantification of cardiac fibrosis by Picrosirius Red staining revealed significant myocardial fibrosis in MLP KO mice that was mildly exacerbated in MLP/DWORF dKO mice and dramatically reduced in MLP KO/DWORF Tg mice at 8 weeks of age (Figure 5A,B). The gene discussed is STRIT1; the disease is Myocardial fibrosis.