STRIT1 and diabetic cardiomyopathy: It has previously been shown that enhancing contractility by overexpressing SERCA is protective against diabetic cardiomyopathy (Trost et al., 2002) as well as cardiac dysfunction induced by chronic pressure overload (Miyamoto et al., 2000; del Monte et al., 2001; Nakayama et al., 2003) and we believe that we can achieve the same results with DWORF overexpression.