Moreover, our previous investigations showed that deglycosylated derivative of ginsenoside Rb3 (Rg3) performed its depression‐inhibiting roles by modulating signaling pathways associated with BDNF and cAMP response element binding protein (CREB) using cellular and animal models (Zhang et al., 2016; Zhang, Zhou, Chen, Zhong, & Zhong, 2017). Here, CREB1 is linked to depressive symptom measurement.