To clarify the interaction of mmu_circ_0001223 with CREB1 and BNDF expression in the pathophysiological processes of depression as well as depression treatment with SLPN, the mmu_circ_0001223 were over‐expressed in cultured PC12 cells by lentiviral expression system (Figure 6a). The gene discussed is CREB1; the disease is depressive symptom measurement.