All variables with statistical significance detected by univariate analysis were included in the multivariate conditional logistic regression model, and multivariate logistic regression analysis revealed that the mutant genotype of rs4148323 in the UGT1A1 gene, ABO incompatibility, G6PD deficiency, and SS genotype at rs1805173 locus of the HO-1 gene were genetic risk factors of neonatal hyperbilirubinemia (Table 5). The gene discussed is HMOX1; the disease is G6PD deficiency.