Particularly worth to mention is for instance calpain -a protein that belongs to the family of calcium-dependent cysteine proteases (Saido et al., 1992) that was demonstrated to truncate N-cadherin and NCAM (Covault et al., 1991; Jang et al., 2009) and its functional role in epilepsy development was confirmed by a recent work of Lam et al. (2017). Here, NCAM1 is linked to epilepsy.