In cancer, MiR-155 and MiR-21 are critically required for the expansion of MDSC in tumor-bearing mice and to facilitate tumor growth; miR 93-106b cluster regulate expression of PD-L1 on MDSC; while a specific role for miR-142-3p has recently been suggested in cancer through preventing differentiation of myeloid cells (Li et al., 2014; Chen et al., 2015b). Here, CD274 is linked to cancer.