During cerebral ischemia reperfusion, astrocytes play a crucial role in limiting neuronal lesion, as they release epoxyeicosanoic acids in order to enlarge brain vessels, release Nerve Growth Factors to make neurons survive and axons grow, produce neurotransmitters, metabolize toxic molecules, and have also the potentiality to become NSCs [23, 24]. Here, NGF is linked to brain ischemia.