It has been shown that LTC4 is able to: (i) potentiate ILC2 activation with increased release of IL-5 (51), which can control homeostatic eosinophilia of adipose tissue (12); and (ii) induce IL-4 secretion from eosinophils (52, 53), therefore with indirect stimulatory impact in M2 macrophage phenotype. Here, IL4 is linked to Increased total eosinophil count.