Interestingly, treatment with common chemotherapeutic compounds (e.g., temozolomide) has been shown to increase expression of stress associated NKG2D ligands on tumor cells, thereby possibly sensitizing tumor cells for Vγ9Vδ2-T recognition and opening windows for Vγ9Vδ2-T based immunotherapies (142). The gene discussed is KLRK1; the disease is neoplasm.