TNF and neoplasm: Vγ9Vδ2 TCR mediated recognition of accumulated pAgs in tumor cells is mediated by BTN3A1/CD277 and results in strong activation and expansion of Vγ9Vδ2-T cells which is marked by the release of multiple pro-inflammatory cytokines including IFNγ, TNF-α and/or interleukin-17 (IL-17 seems to be mostly produced by Vδ1+ cells and it is not just a pro-inflammatory antitumor cytokine) and a strong anti-tumor response (109, 118–120) (Figure 1).