This has e.g., been described by Bruno et al. who identified NK cells in patients with non-small cell lung cancer that produced substantial levels of vascular endothelial growth factor (VEGF), placental growth factor (PIGF) and IL-8 and therefore might stimulate angiogenesis to enhance tumor growth (45, 46) and actively suppress immune responses (47) (Figure 1B). This evidence concerns the gene VEGFA and neoplasm.