For example, in one study, MCP-1 was shown to regulate IL-1β in a feedback loop (24) and since we showed that in colon cancer MK2 regulates the majority of IL-1β production in the colon tumor microenvironment (10), it is important to further study the downstream inflammatory effects of the MK2 pathway. The gene discussed is CCL2; the disease is malignant colon neoplasm.