Endothelial SIRT1 deficiency is a common companion of various cardiovascular, metabolic and renal diseases, as well as of aging (Haigis and Guarente, 2006; Potente et al., 2007; Chen et al., 2012; Maizel et al., 2014; Vasko et al., 2014). This evidence concerns the gene SIRT1 and kidney disorder.