Therefore, it is fair to predict that miRNA(s) which can effectively bind to MICU1 and/or MICU2 mRNAs can influence the [Ca2+]m. In particular, there is great potential for treatment of conditions such as diabetes and cardiovascular disease with MitomiR(s) manipulation due to their impact on the mitochondria and overall cardiac function. The gene discussed is MICU1; the disease is cardiovascular disorder.