Because our group have previously studied that, the bitter compounds or herbal medicines resulted in Gα-gust-mediated GLP-1 release and alleviated hyperglycemia under the condition of oral glucose tolerance in diabetic mice through activation of taste receptor and of its signaling (Kim et al., 2014a; Suh et al., 2015; Kim and Jang, 2016). Here, GLP1R is linked to Hyperglycemia.