CSF tau and FDG-PET display the pathological process of AD after Aβ-plaque deposition and the changes are more obvious between the normal condition and MCI but become less distinct between MCI and AD (Minoshima et al., 1997; Sunderland et al., 1999; Bouwman et al., 2007; Vemuri et al., 2009a). Here, MAPT is linked to Alzheimer disease.