KLF4 and early-onset autosomal dominant Alzheimer disease: Several studies indicate that KLF4 is linked to multiple neurological disorders, including Alzheimer’s disease (AD), epilepsy, Parkinson’s disease, hydrocephalus and schizophrenia (Qin et al., 2011; Xie et al., 2013; Han et al., 2015; Nishiguchi et al., 2015; Li L. et al., 2017).