In fact, studies of sensorineural hearing loss (SNHL) in the aging C57Bl/6 mouse showed while there was broader IC tuning and fewer high-frequency IC neurons, as we have observed with the loss of prestin, there was an increase in IC hyperactivity and this hyperactivity resulted in an increased acoustic startle reflex (Barsz et al., 2007; Xiong et al., 2017). Here, SLC26A5 is linked to sensorineural hearing loss disorder.