Clinical manifestations of the premutation include fragile-X-associated tremor/ataxia syndrome (FXTAS) in adult males (Hagerman and Hagerman, 2013), fragile-X-associated primary ovarian insufficiency (FXPOI), and the fragile-X-associated diminished ovarian reserve (FXDOR) in adult females (Hagerman et al., 2001; Man et al., 2017). This evidence concerns the gene PSMB5 and fragile X-associated tremor/ataxia syndrome.